DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study

• DOI: 10.1002/gcc.22701
• Publication Date: 2018-11-01T10:29:50Z
• Authors: Philip J. Lupo; Austin L. Brown; Vidal M. Arroyo; Kala Y. Kamdar; John W. Belmont; Michael E. Scheurer; Wendy M. Leisenring; M. Monica Gramatges; M. Fatih Okcu; Yutaka Yasui; Kevin C. Oeffinger; Leslie L. Robison; Gregory T. Armstrong; Smita Bhatia
• Keywords: Pediatric cancer; CpG site; Epigenome

Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and at adiposity-associated CpG sites previously-reported by epigenome-wide association studies (EWAS) body mass index (BMI) in the general population. We selected 96 ALL from Childhood Cancer Survivor Study: 48 normal weight. The Illumina HumanMethylation450 BeadChip was used compare 211 loci identified EWAS BMI Thirty-nine were associated (false discovery rate <0.05) with obesity among who only received chemotherapy (n = 49). No significantly CRT-exposed 47). Our results suggest that previously BMI-DNA spared CRT, while no CRT.