Cytogenetic analysis of 63 non‐small cell lung carcinomas: Recurrent chromosome alterations amid frequent and widespread genomic upheaval

• DOI: 10.1002/gcc.2870110307
• Publication Date: 2007-02-21T23:46:03Z
• Authors: Joseph R. Testa; Jill M. Siegfried; Zemin Liu; Jay D. Hunt; Madelyn M. Feder; Samuel Litwin; Jian‐Yuan Zhou; Takahiro Taguchi; Steven M. Keller
• Keywords: Isochromosome; Pathogenesis

Abstract A detailed cytogenetic analysis of 63 non‐small cell lung carcinomas (NSCLCs) was carried out for identification recurrent chromosomal alterations. Most specimens displayed very complex karyotypes with multiple numerical and structural changes (median number, 31). Losses chromosomes 9 (65% cases) 13 (71%) were the most frequent changes. Loss Y often observed in tumors from males. Gain chromosome 7 also (41%). Chromosome arms 1p, 1, 3p, 3q, 6q, 7q, 8q, 9p, 11q, 17p, 19q particularly prone to rearrangement. The arm contributing losses 9p (79%). Other that frequently lost included 8p, 9q, 13q, 18q, 19p, 21q, 22q, short each acrocentric chromosome. percentage cases loss 3p significantly higher squamous (94%) than adenocarcinomas (60%). There a statistically significant increase proportion gains 1q, 7p, 11q compared carcinomas. Several isochromosomes unbalanced exchanges found. Among these i(5p), which nine tumors, eight adenomatous features. An i(8q) identified six cases, including five adenocarcinomas. Double minutes and/or homogeneously staining regions seen seven specimens. These data indicate numerous alterations contribute pathogenesis NSCLC that, amid this widespread genomic disarray, abnormalities exist could have biological clinical implications.