Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

• DOI: 10.1002/glia.23190
• Publication Date: 2017-07-19T11:58:19Z
• Authors: Yasmina Manso; Philip R. Holland; Akihiro Kitamura; Stefan Szymkowiak; Jessica Duncombe; Edel Hennessy; James L. Searcy; Martina Marangoni; Andrew D. Randall; Jon T. Brown; Barry W. McColl; Karen Horsburgh
• Keywords: Minocycline; Neuroglia

Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in vascular disease and dementia. In mouse model relevant to studying disease, we have previously shown that disrupts axon-glial integrity the distribution of paranodal internodal proteins subcortical myelinated axons. This axons accompanied by increased microglia cognitive decline. The aim present study was investigate whether impairs functional matter, its relation microglial number, targeting these effects can be improved. We show response increasing durations hypoperfusion, conduction velocity fibres corpus callosum progressively reduced disrupted. number cells increases correlates disrupted velocities. Further minocycline, proposed anti-inflammatory inhibitor, restores function related reduction microglia. suggests activation contributes structural alterations induced dampening numbers/proliferation should further investigated as potential therapeutic benefit disease.