Association between severe treatment‐related lymphopenia and progression‐free survival in patients with newly diagnosed squamous cell head and neck cancer

• DOI: 10.1002/hed.23535
• Publication Date: 2013-10-31T10:08:31Z
• Authors: Jian L. Campian; Guneet Sarai; Xiaobu Ye; Shanthi Marur; Stuart A. Grossman
• Keywords: Squamous cell cancer

Severe treatment-related lymphopenia occurs commonly in many cancers and is associated with early tumor progression. Data are lacking as to whether this squamous cell head neck cancer.Serial total lymphocyte counts were retrospectively reviewed patients newly diagnosed cancer undergoing chemoradiation treatment outcomes.The median baseline count 56 was 1660 cells/mm(3) , which fell by 73% 445 2 months after initiating (p < .0001). Human papillomavirus negative (HPV-) a <500 at had significantly earlier disease progression than those higher (hazard ratio [HR], 5.75; p = .045).Baseline normal, but approximately 60% of severe regardless HPV status. HPV- independently Prospective studies needed confirm these findings, suggest that immune preservation important cancer.