Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification

• DOI: 10.1002/hed.24452
• Publication Date: 2016-04-04T15:49:12Z
• Authors: Maxime Mermod; Massimo Bongiovanni; Tatiana V. Petrova; Elena A. Dubikovs...; Christian Simon; Genrich Tolstonog; Yan Monnier
• Keywords: Occult; Lymphatic vessel; Lymphatic Endothelium

Abstract Background The use of lymphatic vessel density as a predictor occult lymph node metastasis (OLNM) in head and neck squamous cell carcinoma (HNSCC) has never been reported. Methods Staining the specific endothelial cells nuclear marker, PROX1, an indicator was determined by counting number positive carcinomas (SCCs) oral cavity oropharynx with clinically negative necks. Correlation histopathological data established. Results Peritumoral PROX1 count significantly correlated detection OLNM multivariate analysis ( p < .005). sensitivity, specificity, predictive value (PPV), (NPV) this parameter 60%, 95%, 85%, 90%, respectively. Conclusion primary SCCs allows accurate prediction metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1407–1415,