Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

• DOI: 10.1002/hed.25420
• Publication Date: 2018-12-24T03:19:06Z
• Authors: Michael Fattouh; Gina Y. Chang; Thomas J. Ow; Keivan Shifteh; Gregory Rosenblatt; Viraj M. Patel; Richard V. Smith; Michael B. Prysto...; Nicolas F. Schlecht
• Keywords: 2. Zero hunger; Male; Sarcopenia; Squamous Cell Carcinoma of Head and Neck; Middle Aged; 3. Good health; Body Mass Index; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Head and Neck Neoplasms; Risk Factors; Humans; Female; Obesity; Aged; Retrospective Studies

Abstract Background Body mass index (BMI), sarcopenia, and obesity‐related comorbidities have been associated with head neck squamous cell carcinoma (HNSCC) progression. Methods We conducted a retrospective analysis of 441 normal‐weight, overweight, obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment assessed for differences in survival adjusting comorbid conditions (cardiovascular disease diabetes). Evidence sarcopenia was also using pretreatment abdominal CT scans subset 113 patients. Results Prior treatment, 55% overweight or obese. Overweight/obese had significantly better overall (hazard ratio [HR] = 0.4, 95% CI: 0.3‐0.6) compared normal‐weight patients, independent conditions. poorer (HR 2.1, 1.1‐3.9) non‐sarcopenic the strongest association seen among overweight/obese Conclusion Our data support importance assessment, addition BMI, HNSCC.