Tumor Necrosis Factor and Endotoxin in the Pathogenesis of Liver and Pulmonary Injuries After Orthotopic Liver Transplantation in the Rat

• DOI: 10.1002/hep.1840160230
• Publication Date: 2007-03-04T01:12:14Z
• Authors: Moritaka Goto; Yoshiyuki Takei; Sunao Kawano; Shingo Tsuji; Hiroyuki Fukui; Hiroaki Fushimi; Yoshiya Nishimura; Toru Kashiwagi; Hideyuki Fusamoto; Takenobu Kamada
• Keywords: Pathogenesis

This study examines whether tumor necrosis factor and endotoxin are involved in the pathogenesis of primary nonfunction graft pulmonary complication after orthotopic liver transplantation. Livers from Lewis rats were stored for either 1 or 4 hr ice-cold Euro-Collins solution (1-hr storage 4-hr group, respectively). Subsequently, donor livers implanted orthotopically. In some experiments, anti-tumor antibody was administered intravenously before immediately surgery into animals that received hr. Blood samples measurement collected by way an indwelling catheter placed suprahepatic vena cava. Serum elevated at all time points studied postoperatively group; however, not detected serum 1-hr group. Endotoxin also significantly former group compared with levels latter The peak value occurred earlier than factor, suggesting rise stimulated release factor. histological showed substantial hepatocellular degeneration 24 surgery, whereas damage minimal ALT operation groups 169 +/- 46 IU/L 374 41 (mean S.E.M., p less 0.05), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)