Increased Fructose Consumption Is Associated With Fibrosis Severity in Patients With Nonalcoholic Fatty Liver Disease

• DOI: 10.1002/hep.23535
• Publication Date: 2010-01-28T15:04:32Z
• Authors: Manal F. Abdelmalek; Ayako Suzuki; Cynthia Guy; Aynur Unalp-Arida; Ryan Colvin; Richard J. Johnson; Anna Mae Diehl
• Keywords: Adult; Male; 2. Zero hunger; Age Factors; Fructose; Middle Aged; Fibrosis; Diet; 3. Good health; Fatty Liver; Cross-Sectional Studies; Liver; Humans; Female

The rising incidence of obesity and diabetes coincides with a marked increase in fructose consumption. Fructose consumption is higher individuals nonalcoholic fatty liver disease (NAFLD) than age-matched body mass index (BMI)-matched controls. Because elicits metabolic perturbations that may be hepatotoxic, we investigated the relationship between severity NAFLD. We studied 427 adults enrolled NASH Clinical Research Network for whom Block food questionnaire data were collected within 3 months biopsy. was estimated based on reporting (frequency × amount) Kool-aid, fruit juices, nondietary soda intake, expressed as servings per week, classified into none, minimum to moderate (<7 servings/week), daily (≥7 servings/week). association intake histological features NAFLD analyzed using multiple linear ordinal logistic regression analyses without controlling other confounding factors. Increased univariately associated decreased age ( P < 0.0001), male sex hypertriglyceridemia 0.04), low high-density lipoprotein (HDL) cholesterol (<0.0001), serum glucose 0.001), increased calorie hyperuricemia 0.0001). After age, sex, BMI, total lower steatosis grade fibrosis stage 0.05 each). In older (age ≥ 48 years), hepatic inflammation 0.05) hepatocyte ballooning = 0.05). Conclusion : patients NAFLD, ingestion reduced but fibrosis. These results identify readily modifiable environmental risk factor ameliorate progression Hepatology 2010