Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma

• DOI: 10.1002/hep.26311
• Publication Date: 2013-02-06T18:12:01Z
• Authors: Xi-Dai Long; Jin-Guang Yao; Zhi Zeng; Yun Ma; Xiao-Ying Huang; Zhong-Hua Wei; Min Liu; Jian-Jun Zhang; Feng Xue; Bo Zhai; Qiang Xia
• Keywords: DNA-Binding Proteins; 0301 basic medicine; DNA Adducts; 03 medical and health sciences; Aflatoxin B1; Carcinoma, Hepatocellular; Liver Neoplasms; Biomarkers, Tumor; Humans; Neoplasm Metastasis; Prognosis; 3. Good health

X-ray repair complementing group 4 (XRCC4) is very important in maintaining overall genome stability and may play an role carcinogenesis. We aimed to investigate the of polymorphisms coding region this gene hepatocellular carcinoma (HCC) caused by aflatoxin B1 (AFB1). A hospital-based case-control study, including 1,499 HCC cases 2,045 controls without any liver diseases or tumors, was conducted a high AFB1 exposure area (the Guangxi region) assess relationship between 21 XRCC4 AFB1-related risk prognosis. Among these polymorphisms, only rs28383151 modified risk. These individuals with genotypes alleles (rs28383151-GA/AA), compared homozygote G (rs28383151-GG), faced increasing (odds ratio [OR]: 2.17; 95% confidence interval: 1.77-2.67). Significant interactive effects (OR, >1) status were also observed joint-effects analysis. Furthermore, polymorphism correlated not lower XRCC4-expressing levels, but higher AFB1-DNA adducts levels TP53M portal vein tumor The recurrence-free survival patients, especially under conditions. Additionally, multiplicatively interacted glutathione S-transferase M1 respect (ORinteraction = 2.13).Genetic be prognostic biomarkers HCC, such potential candidate.