Visceral adiposity increases risk for hepatocellular carcinoma in male patients with cirrhosis and recurrence after liver transplant

• DOI: 10.1002/hep.29578
• Publication Date: 2017-10-10T23:52:40Z
• Authors: Aldo J. Montano‐Loza; Vera C. Mazurak; Maryam Ebadi; Judith Meza‐Junco; Michael B. Sawyer; Vickie E. Baracos; Norman Kneteman
• Keywords: Adult; Liver Cirrhosis; Male; 0303 health sciences; Carcinoma, Hepatocellular; Databases, Factual; Liver Neoplasms; Kaplan-Meier Estimate; Intra-Abdominal Fat; Middle Aged; Liver Transplantation; 3. Good health; Young Adult; 03 medical and health sciences; Risk Factors; Humans; Neoplasm Recurrence, Local; Tomography, X-Ray Computed; Adiposity; Aged; Retrospective Studies

Visceral adipose tissue (VAT) is a metabolically active organ, associated with higher risk of malignancies. We evaluated whether VAT the hepatocellular carcinoma (HCC) in patients presenting cirrhosis as well HCC recurrence after liver transplantation (LT). Patients (n = 678; 457 male) who were assessed for LT (289 HCC) body composition analysis. underwent 247, 168 subsequently composition, and 96 these (78 had HCC. VAT, subcutaneous tissues, total tissues quantified by computed tomography at level third lumbar vertebra reported indexes (cross‐sectional area normalized height [square centimeters per square meter]). At time assessment, index (VATI) was male compared to non‐HCC (75 ± 3 versus 60 cm 2 /m , P 0.001). The VATI, index, patients. By multivariate analysis, VATI ≥65 (hazard ratio, 1.90; 95% confidence interval, 1.31‐2.76; In LT, adjusted Milan criteria independently 5.34; 1.19‐23.97; 0.03). Conclusion: High an independent factor LT. (H epatology 2018;67:914–923)