Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma

• DOI: 10.1002/hep.31391
• Publication Date: 2020-05-27T23:15:59Z
• Authors: Zoe Hall; Davide Chiarugi; Evelina Charidemou; Jack Leslie; Emma Scott; Luca Pellegrinet; Michael Allison; Gabriele Mocciaro; Quentin M. Anstee; Gerard I. Evan; Matthew Hoare; Antonio Vidal‐Puig; Fiona Oakley; Michele Vacca; Julian L. Griffin
• Keywords: Liver Regeneration

Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC). However, the control of these processes is not fully understood. In order capture signature proliferating hepatocytes, we applied state-of-the-art systems biology approaches models liver regeneration, pharmacologically genetically activated cell proliferation, HCC.