First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study

• DOI: 10.1002/inmd.20240048
• Publication Date: 2024-10-28T13:40:24Z
• Authors: Zeyu Zhang; Lishuang Guo; Lan Yao; Yueyue Li; Yan Hei; Qi Wang; Xiaoyi Wang; Rui Ma; Xinji Yang; Zhenhua Hu; Wei Wu
• Keywords: Fluorescence-lifetime imaging microscopy

Abstract Precise resection of orbital tumors is a critically important but elusive issue. Fluorescence imaging in the near‐infrared II window (NIR‐II) holds potential to provide surgeons with real‐time identification for tumors. Here, first time, we evaluated feasibility and clinical value NIR‐II fluorescence tumor surgery. To establish method tumors, developed system indocyanine green (ICG) served as fluorescent contrast agent. Twenty‐two patients diagnosed scheduled standard‐of‐care surgery were enrolled this study. Time‐course two superficial showed optimum time was 2 h post injection ICG. Fifteen allocated diagnostic test, which that both situ ex vivo better sensitivity specificity than surgeon judgment. In trial remaining five patients, encountered 34 suspicious regions surgical decisions changed nine times due imaging. The resultant seven additional resections justified by histopathology conservative treatments did not result recurrence. Based on these findings, suggested ICG‐based feasible guide precise A future randomized controlled larger cohort encouraged further verify value.