Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment

• DOI: 10.1002/inmd.20240124
• Publication Date: 2025-04-01T17:09:45Z
• Authors: Zhongyi Sun; Haibo Liu; Mengting Yin; Ningning Cheng; Wencheng Liu; Kangkang Zhao; Hua Zeng; Xuming Chen; Zijie Wang; Xuhui Zhou; Xinyu Zhao; Feng Chen

Abstract Radiotherapy induced skin defect (RISD) is a severe radiotherapy complication with persistent oxidative stress and recurrent excessive reactive oxygen species (ROS), impeding normal tissue repair processes. Nevertheless, the lack of standardized animal model severely hinders progress related research work. We develop novel strategy for repairing RISD microenvironment, which combines initial ROS clearance, subsequent inhibition production proliferation cell pathways/functions. As proof concept, composite microneedle (MN) patch comprising γ‐polyglutamic acid as base ruthenium (Ru) clusters modified magnesium silicate nanosheets (MSR NSs) enzyme‐like component prepared. The Ru have excellent scavenging ability help activate peroxisome proliferators activated receptor signaling pathway confirmed by sequencing analysis while degraded under physiological conditions to release ions ions, enhancing proliferation, migration, angiogenesis ability. radiation established evaluate efficacy our MSR@MN in comparison γPGA‐MSR ointment commercial product Orgotein. results show that effectively improves pathological microenvironment abnormal accumulation, reduces inflammatory response promotes mature remodeling.