Matrix metalloproteinases 2 and 9 in central nervous system and their modification after vanadium inhalation

• DOI: 10.1002/jat.1326
• Publication Date: 2007-12-05T15:46:59Z
• Authors: L. Colín‐Barenque; M. G. Martínez‐He...; L. A. Baiza‐Gutman; M. R. Avila‐Costa; J. L. Ordóñez‐Lib...; P. Bizarro‐Nevares; V. Rodriguez‐Lara; G. Piñón‐Zarate; M. Rojas‐Lemus; P. Mussali‐Galante; T. I. Fortoul
• Keywords: Piriform cortex

Abstract Vanadium (V) derivatives are well‐known environmental pollutants and its toxicity has been related with oxidative stress. Toxicity after vanadium inhalation on the substantia nigra, corpus striatum, hippocampus ependymal epithelium was reported previously. The purpose of this study to analyse role matrix metalloproteinases 2 (MMP‐2) 9 (MMP‐9) in changes observed brain tissue chronic V inhalation. Mice were exposed vaporized, pentoxide 0.02 m deionized water for 1 h twice a week, killed at h, 1, 4 weeks exposure. removed olfactory bulb, prefrontal cortex, striatum dissected MMP content obtained by zymography. results showed that MMP‐9 increased all structures end exposure, although increment evident week When MMP‐2 analysed bulb cortex it remained unchanged throughout whole while 4, from second only, through experiment. These demonstrate MMPs different CNS change might be associated previously modifications, such as dendritic spine loss neuronal cell death. modifications could blood–brain barrier (BBB) disruption which Oxidative stress also involved activation these gelatinases part mechanisms take place CNS. Copyright © 2007 John Wiley & Sons, Ltd.