Biodegradable AZ91 magnesium alloy/sirolimus/poly D, L‐lactic‐co‐glycolic acid‐based substrate for cardiovascular device application

• DOI: 10.1002/jbm.b.35350
• Publication Date: 2023-11-15T21:37:24Z
• Authors: Monalisha Mohanta; Yugesh Ramdhun; Arunachalam Thiru...; Ritvesh Gupta; Devendra Verma; Thirumalai Deepak; Anju R. Babu
• Keywords: PLGA; Glycolic acid

Abstract Biodegradable drug‐eluting stents (DESs) are gaining importance owing to their attractive features, such as complete drug release the target site. Magnesium (Mg) alloys promising materials for future biodegradable DESs. However, there few explorations using Mg cardiovascular stent application. In this present study, sirolimus‐loaded poly D, L‐lactic‐co‐glycolic acid (PLGA)‐coated/ sirolimus‐fixed/AZ91 alloy‐based substrate was developed via a layer‐by‐layer approach The AZ91 alloy prepared through squeeze casting technique. casted alkali‐treated provide macroporous networks hold sirolimus and PLGA layers. systematic characterization investigated electrochemical, optical, physicochemical, in‐vitro biological characteristics. presence of 17 Al 12 phase in sample found x‐ray diffraction system (XRD) spectrum which influences corrosion behavior substrate. alkali treatment increases substrate's hydrophilicity confirmed static contact angle measurement. anti‐corrosion characteristic casted‐AZ91 slightly less than PLGA‐coated (Mg/Na/S/P) dissolution rates both substrates were be controlled at cell culture conditions. Radiographic densities (Mg, Mg/Na, Mg/Na/S/P) measured 0.795 ± 0.015, 0.742 0.01, 0.712 0.017, respectively. star‐shaped structure 12% sirolimus/PLGA ensures bioavailability drugs. Sirolimus kinetic fitted up 80% with “Higuchi model” samples, whereas Mg/Na/S/P showed 45% fitting zero‐order mechanism. 70% antithrombotic effect compared control . Further, enhances antibacterial alloy. Also, (Mg/Na/S inhibit valvular interstitial cell's growth significantly in‐vitro. Hence, results imply that can potential candidate