Compressive Strength of Iliac Bone ECM Is Not Reduced in Osteogenesis Imperfecta and Increases With Mineralization

• DOI: 10.1002/jbmr.4286
• Publication Date: 2021-03-19T18:21:53Z
• Authors: Michael Indermaur; Daniele Casari; Tatiana Kochetkova; Cinzia Peruzzi; Elizabeth Zimmermann; Frank Rauch; Bettina Willie; Johann Michler; Jakob Schwiedrzik; Philippe Zysset
• Keywords: Iliac crest; Type I collagen

Osteogenesis imperfecta (OI) is an inheritable, genetic, and collagen-related disorder leading to increase in bone fragility, but the origin of its "brittle behavior" unclear. Because complex hierarchical structure, behaves differently at various length scales. This study aims compare mechanical properties human OI with healthy control extracellular matrix (ECM) level quantify influence degree mineralization. Degree mineralization were analyzed under dry conditions 12 fixed embedded transiliac crest biopsies (control n = 6, type I 3, IV 2, III 1). Mean was measured by microcomputed tomography biopsy mineral-to-matrix ratio assessed Raman spectroscopy ECM level. Both methods revealed that higher for compared control. Micropillar compression a novel technique quantifying post-yield Micropillars (d 5 μm, h 10 μm) fabricated using focused ion beam milling quasi-statically compressed capture key such as ultimate strength. The qualitative inspection stress-strain curves showed both have ductile response quantitative results compressive strength not reduced increasing severity. Nanoindentation measurements tends Young's modulus, hardness, dissipated energy bone. indentation modulus increased linearly significantly (p < .0001) ratio. In conclusion, this indicates iliac are inferior © 2021 Authors. Journal Bone Mineral Research published Wiley Periodicals LLC on behalf American Society (ASBMR).