Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling

• DOI: 10.1002/jcb.26745
• Publication Date: 2018-01-31T18:38:31Z
• Authors: Yu‐Heng V. Ma; Candy Lam; Shreyash Dalmia; Peter Gao; Jacob Young; Kevin Middleton; Chao Liu; Henry Xu; Lidan You
• Keywords: Osteocyte

Bone metastases, the migration of cancers to bone, occur in 65-80% patients with advanced breast cancer. Metastasized cancer cells interact such as bone-resorbing osteoclasts alter bone remodeling. Exercise, often suggested an intervention for patients, regulates remodeling via osteocytes. Osteocytes also signal endothelial cells, which may affect cell extravasation. Therefore, we hypothesize that mechanically stimulated osteocytes can regulate processes metastasis. To test this, exposed oscillatory fluid flow vitro using parallel-plate chambers. We observed conditioned medium from flow-stimulated increased (by 45%) and reduced apoptosis 12%) cells. Conditioned flowed osteocytes' 47%) 55%) Cancer trans-endothelial was by 34% toward medium. This difference abolished ICAM-1 or IL-6 neutralizing antibodies. 29%. summarize, this study demonstrated potential not only through direct signaling, but The anti-metastatic indirect signalings is particularly exciting since are further away metastasizing than Future studies into effect mechanical loading on metastases its mechanism will assist designing programs lowers risk metastases.