MicroRNA‐628‐5p inhibits cell proliferation in glioma by targeting DDX59

• DOI: 10.1002/jcb.28991
• Publication Date: 2019-05-21T04:33:00Z
• Authors: Peng Xie; Yan Wang; Yuanmei Liao; Qiu Han; Zhichao Qiu; Yinbing Chen; Xiaohua Zuo
• Keywords: 0301 basic medicine; Mice, Inbred BALB C; Brain Neoplasms; Cell Cycle; Mice, Nude; Apoptosis; Glioma; Prognosis; Xenograft Model Antitumor Assays; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; 03 medical and health sciences; Biomarkers, Tumor; Tumor Cells, Cultured; Animals; Humans; RNA Helicases; Cell Proliferation

Recent study has reported that microRNA-628-5p (miR-628-5p) is involved in the development of epithelial ovarian cancer; however, mechanisms miR-628-5p glioma remain unclear. In this study, we explored potential biological roles glioma. First, found was decreased tissues and cells (U87 T98) Second, overexpressing reduced ability cells' proliferation induced cycle arrest G1. Then, directly bound to 3'-untranslated region DDX59 protein level DDX59. The decrease lead p-AKT. Mechanistic studies revealed restoring expression alleviated miR-628-5p-induced inhibition These findings suggest miR-628-5p/DDX59 axis a key role glioma, might be new therapeutic target against