Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca

• DOI: 10.1002/jccs.202000156
• Publication Date: 2020-09-21T19:18:50Z
• Authors: Tarik A. Mohamed; Abdelsamed I. Els...; Ahmed M. Abd‐ElGawad; Taha A. Hussien; Sayed A. El‐Toumy; Thomas Efferth; Mohamed‐Elamir F....
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

AbstractThe aerial parts of Centaureaa egyptiaca afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) (1), rediolpidetriol (2), linichlorinA (3), and sinaicin (4), one monoterpene; loliolid (5), one phenolic: tyrosol (6), three lignans; arctigenin (7), matairesinol (8), and pinoresinol (9), and one steroid; ergosta‐5,22‐dien‐3‐ol (10). The cluster analysis of 32 Centaurea species revealed that C. aegyptiaca is closely related to C. repens and C. solstitialise. The isolated compounds (1–10) were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53+/+) colon carcinoma cell lines. Compounds1 and 2 were the most potent compounds against both leukemia and breast carcinoma cell lines.