Encapsulation of vortioxetine with cyclodextrins via host–guest inclusion complex: Synthesis, characterization, solubility, and in vitro dissolution studies

• DOI: 10.1002/jccs.202200554
• Publication Date: 2023-03-22T05:19:26Z
• Authors: Muhammad Inam; Chi Uyen Phan; Jian‐Wei Wang; Muhammad Jamshed; Xiurong Hu; Guping Tang
• Keywords: Inclusion compound; Recrystallization (geology); Distilled water

Abstract Drug solubility plays a significant role in the development of drug formulation. The objectives this work are to improve and dissolution rate vortioxetine (VT) by preparing its inclusion complexes (ICs) with β‐Cyclodextrin (β‐CD) γ‐Cyclodextrin (γ‐CD). ICs were prepared 1:1 M ratio via recrystallization method characterized P‐XRD, FT‐IR, 1 H NMR, 2D NOESY, DSC. Further, crystal structure VT‐β‐CD was analyzed SC‐XRD. P‐XRD data obtained for describe crystalline pattern. DSC analysis shows change thermal behavior VT, CDs ICs. FT‐IR shifting frequencies when compared pristine VT CDs. NOESY DMSO‐d 6 indicates weak interaction between CD molecules. consists one guest host CD, nine water molecules lattice. significantly improved distilled water, pH 1.2 acidic, phosphate buffer 6.8 medium, as drug. vitro different media investigated, which higher than that commercial product VT.