Synthesis, Docking, and Evaluation of Antimicrobial Activity of a New Series of Acyclo C‐Nucleosides of 1, 2, 4‐Triazolo[4, 3‐a]quinoxaline Derivatives

• DOI: 10.1002/jhet.2396
• Publication Date: 2015-01-26T09:47:30Z
• Authors: Mohammed Salah Ayoup; Hany Emary Ali Ahmed; Abdel Moneim El M...; Samir Senior; Sherine Nabil Kha...; Seham Yassen Hassan; Adel Amer
• Keywords: Quinoxaline; Docking (animal); Moiety; Structure–activity relationship

In this study, 18 new 3‐benzylquinoxalinyl hydrazones bearing carbohydrate moiety and their corresponding triazoloquinoxalines were synthesized in order to investigate possible antibacterial antifungal activities. Some of these compounds such as 4b , 4c 7b 7c 7d showed promising activities found have more potent activity compared with that standard drugs. From structure–activity relationship point view, increasing the size substitutions at position 6 or 7 on quinoxaline nucleus decreased antimicrobial activity, while presence hydroxyl groups C2 (R) C3 (S) sugar moieties enhanced activity. Further, molecular docking studies active performed different targets belonging microorganisms good scoring further understanding various interactions sites interesting enzymes co‐crystallized ligands.