Optimizing autologous bone contribution to implant osseointegration

• DOI: 10.1002/jper.19-0524
• Publication Date: 2020-04-12T06:23:18Z
• Authors: Benjamin R. Coyac; Qiang Sun; Brian Leahy; Giuseppe Salvi; Xue Yuan; John B. Brunski; Jill A. Helms
• Keywords: Dental Implants; Titanium; 0303 health sciences; 03 medical and health sciences; Osseointegration; Osteogenesis; Periodontal Ligament; Dental Implantation, Endosseous; Animals; Rats

Autologous bone can be harvested from the flutes of a conventional drill or scraper; here we compared whether autologous chips generated by new slow-speed instrument were more osteogenic than drills scrapers. Additionally, tested potential could further improved exposure to Wnt signaling (WNT) therapeutic.Osteotomies prepared in fresh rat maxillary first molar extraction sockets using osseo-shaping instrument; titanium alloy implants placed immediately thereafter. Using molecular/cellular and histologic analyses, fates resulting analyzed. To test increasing WNT osteogenesis an immediate post-extraction implant environment, therapeutic was introduced at time placement.Bone collected exhibited extensive apoptosis; contrast, remained situ, which preserved their viability. Also viability osteoprogenitor cells attached chips. Exogenous treatment with increased rate around implants.Compared scrapers, cutting enabled concomitant site preparation chip collection. Histology/histomorphometric analyses revealed that this tool enhanced therapeutic. Even though gaps still existed placebo controls liposomal WNT3A (L-WNT3A) cases, area peri-implant significantly greater L-WNT3A treated sites.