Alteration of serum bile acids in amyotrophic lateral sclerosis

• DOI: 10.1002/lipd.12390
• Publication Date: 2024-02-07T08:45:05Z
• Authors: Ikjae Lee; Renu Nandakumar; Rebecca A. Haeusler
• Keywords: Lipidology; Neurochemistry

Hydrophilic endogenous bile acids ursodeoxycholic acid (UDCA), tauroursodeoxycholic (TUDCA), and glucourosodeoxycholic (GUDCA) have suggested neuroprotective effects. We performed a case-control study to examine the association between ALS diagnosis serum levels of acids. Sporadic familial patients, age- sex-matched healthy controls, presymptomatic gene carriers who donated blood samples were included. Non-fasted stored at -80°C used for analysis. Serum measured by liquid chromatography-mass spectrometry (LC-MS). Concentrations 15 obtained, 5 non-conjugated 10 conjugated, compared versus control groups (presymptomatic + controls) using Wilcoxon-Rank-Sum test. In total, 80 participants included: 31 (17 sporadic 14 ALS); 49 controls (22 carriers, 27 controls). The mean age was 50 years old 50% male. group, 45% had disease with pathogenic variant in C9orf72 (29%), TARDBP (10%), FUS (3%), CHCHD10 (3%) genes. 43% carried variants: (27%), SOD1 (6%). UDCA, TUDCA, GUDCA trended higher group (median vs. 7 nM, 4 3 110 47 p-values 0.04, 0.06, respectively). No significant differences found other levels. conclusion, level patients no evidence deficiencies found.