3D‐Printed Porous Tantalum Coated with Antitubercular Drugs Achieving Antibacterial Properties and Good Biocompatibility

• DOI: 10.1002/mabi.202100338
• Publication Date: 2021-10-28T08:19:45Z
• Authors: Long Hua; Hu Qian; Ting Lei; Yu Zhang; Pengfei Lei; Yihe Hu
• Keywords: Biocompatibility; 3d printed

Treatment of bone and joint tuberculosis remains a challenge. The development tissue-engineered drug-loaded biomaterials has increased the therapeutic options. However, for treatment osteoarticular with severe local infection risks high weight-bearing requirements, it is still necessary to design materials consistent biomechanics, cytocompatibility, osteogenesis provide more effective antimicrobial functions. antitubercular drugs isoniazid rifampicin are loaded gellan gum, 3D-printed porous tantalum surface treated polydopamine increase adhesion. osteogenic induction differentiation tested using alkaline phosphatase, alizarin red staining, sirius polymerase chain reaction testing. Bone regeneration in vivo measured by X-ray, micro-computerized tomography, hard tissue sections, fluorescence staining. drug released slowly vitro vivo, increasing duration antibacterial action. composite bio-scaffolds inhibit Staphylococcus aureus growth, have good biocompatibility, does not rat marrow mesenchymal stem cells. bio-scaffold can simultaneously achieve localized long-term controlled release promising route treatment.