Apraxia of Lid Opening in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease—Frequency, Risk Factors and Response to Treatment

• DOI: 10.1002/mdc3.13206
• Publication Date: 2021-04-01T06:12:27Z
• Authors: Syam Krishnan; Kuldeep Shetty; Divya Kalikavil P...; Krishnakumar Kesa...; Jissa Vinoda Thul...; Gangadhara Sarma; Asha Kishore
• Keywords: Subthalamic Nucleus; Apraxia; Movement Disorders

New-onset apraxia of lid opening (ALO) is reported to occur in Parkinson's disease (PD) patients following Deep Brain Stimulation (DBS). There are only few systematic studies on this uncommon disorder eyelid movements.We aimed examine the frequency, temporal evolution, predisposing factors and response treatment, new-onset ALO PD who underwent bilateral subthalamic nucleus (STN) DBS.We retrospectively reviewed data STN DBS at our centre between 1999 2017, with a minimum 2 years follow up after surgery.New-onset was seen 17 (9.1%) 187 an average 16.9 months (Range - 6-36 months). Comparison groups without revealed that occurred more often older patients, both onset symptoms surgery those non-tremor dominant subtypes freezing gait baseline. The extent levodopa dose reduction pre-operative severity motor were not risk factors. Response adjustments dopaminergic medications stimulation parameters ill-sustained or nil. Botulinum toxin therapy resulted satisfactory improvement majority.New-onset phenomenon manifests DBS. Development likely be due effects chronic basal ganglia-thalamo-cortical brain stem circuits controlling movements susceptible patients. offers relatively better relief than other strategies.