Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

• DOI: 10.1002/mds.25020
• Publication Date: 2012-05-02T04:44:58Z
• Authors: Kathleen M. Shannon; Ali Keshavarzian; Hemraj B. Dodiya; Shriram Jakate; Jeffrey H. Kordower
• Keywords: Immunostaining; Colocalization; Alpha (finance)

Abstract Background: Despite clinicopathological evidence that Parkinson's disease (PD) may begin in peripheral tissues, identification of premotor is not yet possible. Alpha‐synuclein aggregation underlies pathology, and its presence tissues be a reliable biomarker. Objective: We sought alpha‐synuclein pathology colonic before the development characteristic motor symptoms. Methods: Old colon biopsy samples were available for three subjects with PD. Biopsies obtained 2‐5 years PD onset. performed immunohistochemistry studies Substance P these samples. Results: All showed immunostaining (two, five two first symptom). No similar was seen 23 healthy controls. Staining substance suggested colocalization perikarya neurites. Conclusions: This demonstration tissue prior to onset Additional study required determine whether mucosal biomarker © 2012 Movement Disorder Society