Cordyceps sinensis ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion‐mediated oxidative stress

• DOI: 10.1002/mef2.91
• Publication Date: 2024-07-20T04:07:28Z
• Authors: Ying Zhang; Lirun Zhou; Guangqing Cheng; Yanyan Zhou; Qiuyan Guo; Jiangpeng Wu; Yin K. Wong; Junzhe Zhang; Huan Tang; Jigang Wang
• Keywords: Mitochondrial ROS

Abstract Idiopathic pulmonary fibrosis (IPF) represents a chronic interstitial lung disease with an unclear underlying mechanism and currently lacks definitive treatment. Cordyceps sinensis (CS), renowned for its pharmacological properties in traditional Chinese medicine extensive use treatment, holds promise as therapeutic agent IPF. However, the specific role of CS treating IPF remains unclear. In this study, we aimed to assess efficacy unravel potential mechanisms. Our results demonstrate that treatment effectively mitigated inflammation collagen deposition bleomycin‐induced mice. Proteomics analysis revealed regulation mitochondrial oxidative phosphorylation may serve protective against Further investigation unveiled could suppress excessive production reactive oxygen species tissues induced by bleomycin through moderating expression activity complexes, thus safeguarding integrity function mitochondria. Overall, our findings not only underscore effectiveness preventing but also highlight mitochondrial‐mediated stress promising target