Improving the detection sensitivity of pH‐weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals

• DOI: 10.1002/mrm.26799
• Publication Date: 2017-06-22T03:47:02Z
• Authors: Hye‐Young Heo; Yi Zhang; Tina M. Burton; Shanshan Jiang; Yansong Zhao; Peter C.M. van Zijl; Richard Leigh; Jinyuan Zhou
• Keywords: Magnetization transfer; Penumbra; Stroke; Acute stroke

Purpose To quantify amide protein transfer (APT) effects in acidic ischemic lesions and assess the spatial‐temporal relationship among diffusion, perfusion, pH deficits acute stroke patients. Methods Thirty patients were scanned at 3 T. Quantitative APT (APT # ) measured using an extrapolated semisolid magnetization reference signal technique compared with commonly used MTR asym (3.5ppm) or APT‐weighted parameters. Results The images showed clear lesion, whereas signals slightly hypointense. contrast between normal tissue was more than three times larger (−1.45 ± 0.40% for versus −0.39 0.52% (3.5ppm), P < 4.6 × 10 −4 ). Hypoperfused areas without apparent diffusion coefficient abnormality observed assigned to acidosis penumbra. also benign oligemia. Hyperintense a hemorrhage area one case. Conclusions quantitative study approach enhances MRI sensitivity conventional MRI, allowing reliable delineation of Magn Reson Med 78:871–880, 2017. © 2017 International Society Magnetic Resonance Medicine.