Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults

• DOI: 10.1002/oby.20235
• Publication Date: 2013-03-16T09:20:42Z
• Authors: Steven K. Malin; Joy Nightingale; Sung‐Eun Choi; Stuart R. Chipkin; Barry Braun
• Keywords: Aerobic Exercise

Abstract Impaired glucose tolerant (IGT) adults are at elevated risk for cardiovascular disease (CVD). Exercise or metformin reduce CVD risk, but the efficacy of combining treatments is unclear. Objective: To determine effects exercise training plus (EM), compared with each treatment alone, on factors in IGT adults. Design and Methods: Subjects were assigned to placebo (P), (M), (EP), EM (8/group). In a double‐blind design, P 2,000 mg/d M administered 12 weeks half performed aerobic resistance 3 days/week ∼60 min/day 70% pretraining heart rate peak. Outcomes included adiposity, blood pressure (BP), lipids, high sensitivity C‐reactive protein (hs‐CRP). Z‐scores calculated metabolic syndrome severity. Results: EM, not EP, decreased body weight ( < 0.05). EP lowered systolic by 6% 0.05), diastolic hs‐CRP 20% (M: trend = 0.06; EP: 0.05) P. Treatments raised high‐density lipoprotein cholesterol 0.05; EM: 0.06) triacyglycerol Z‐score baseline (EP; 0.07 M; Conclusions: Although and/or improve some factors, only alone BP. Thus, may attenuate severity