Myocardial deformation and twist mechanics in adults with metabolic syndrome: Impact of cumulative metabolic burden

• DOI: 10.1002/oby.20537
• Publication Date: 2013-06-26T18:26:19Z
• Authors: Edward Crendal; Guillaume Walther; Agnes Vinet; Frédéric Dutheil; Geraldine Naughton; Bruno Lesourd; Robert Chapier; Thomas Rupp; Daniel Courteix; Philippe Obert
• Keywords: Speckle tracking echocardiography; Abdominal obesity; Subclinical infection

Objective The aim of the study is to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate effects multiple risk‐factors on function using speckle tracking echocardiography (STE); a more sensitive method than conventional for detecting subclinical dysfunction. Design Methods Cross‐sectional analyses 92 (50–70 years) MetS, 50 healthy controls included echocardiography, blood biochemistry, STE‐derived longitudinal, circumferential, twist mechanics. Results Using measures, MetS participants revealed LV hypertrophy reduced diastolic compared controls, while systolic was preserved. From STE, showed attenuated longitudinal strain (−16.8% ± 2.8% vs. −20.6% 2.7%), both (1.1 0.2 1.4 0.3 s −1 ) (−1.0 0.1 −1.2 rate (SR). Circumferential strain, SR, did not differ. Participants highest number factors or diabetes demonstrated greatest reduction SR. Abdominal obesity, TNF‐α, HbA 1c , dyssynchrony explained 48% impairment strain. Conclusions Impaired function, but preserved circumferential were found participants, indicative altered subendocardial function. This dysfunction best predicted by abdominal inflammation, glucose‐intolerance, dyssynchrony.