Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice

• DOI: 10.1002/oby.20578
• Publication Date: 2013-07-25T22:42:58Z
• Authors: Elke Binder; Francisco Javier ...; Melissa Elie; Thierry Leste‐Las...; Ilaria Belluomo; Samantha Clark; Adeline Duchampt; Gilles Mithieux; Daniela Cota
• Keywords: Respiratory quotient; Carbohydrate Metabolism; Diet-induced obese

Objective High‐protein diets favor weight loss and its maintenance. Whether these effects might be recapitulated by certain amino acids is unknown. Therefore, the impact of leucine supplementation on energy balance associated metabolic changes in diet‐induced obese (DIO) mice during after was investigated. Methods DIO C57BL/6J were fed a normocaloric diet to induce while receiving or not acid drinking water. Body weight, food intake, body composition, expenditure, glucose tolerance, insulin, leptin sensitivity evaluated. Q‐PCR analysis performed muscle, brown white adipose tissues. Results decreased fat mass response chow, but with did affect parameters. During maintenance, supplemented had improved increased sensitivity, lower respiratory quotient. The latter expression several genes modulating fatty metabolism mitochondrial activity epididymal tissues, muscle. Conclusions Leucine represent an adjuvant beneficial nutritional therapy because it improves lipid restores previously animals.