Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity

• DOI: 10.1002/oby.23317
• Publication Date: 2021-12-21T19:32:36Z
• Authors: Meredith A. Ware; Jill L. Kaar; Cecilia Diniz Behn; Kai Bartlette; Anne‐Marie Carreau; Dan Lopez‐Paniagua; Ann Scherzinger; Danielle Xie; Haseeb Rahat; Yesenia Garcia‐Reyes; Kristen J. Nadeau; Melanie Cree‐Green
• Keywords: Steatosis

Abstract Objective Adolescents with polycystic ovary syndrome (PCOS) and obesity can have insulin resistance, dysglycemia, hepatic steatosis. Excess pancreatic fat may disturb secretion relate to fat. Associations between fraction (PFF) metabolic measures in PCOS were unknown. Methods This secondary analysis included 113 sedentary, nondiabetic adolescent girls (age = 15.4 [1.9] years), or without BMI ≥ 90th percentile. Participants underwent fasting labs, oral glucose tolerance tests, magnetic resonance imaging for (HFF) PFF. Groups categorized by PFF (above below the median of 2.18%) compared. Results Visceral HFF elevated individuals versus control individuals, but was similar. did not correlate serum androgens. Higher lower groups had similar HFF, no correlation although steatosis more common those higher (≥5.0% HFF; 60% vs. 36%; p 0.014). The group ( 0.026), resistance (homeostatic model assessment 0.032; 1/fasting insulin, 0.028), free fatty acids 0.034), triglycerides 0.004) compared β‐Cell function sensitivity groups. Conclusions Neither status nor androgens related However, postprandial lipids worse