Maternal macronutrient intake effects on offspring macronutrient targets and metabolism

• DOI: 10.1002/oby.23995
• Publication Date: 2024-02-08T10:19:08Z
• Authors: Therese Freire; Ximonie Clark; Tamara Pulpitel; Kim Bell‐Anderson; Rosilene Ribeiro; David Raubenheimer; Angela J. Crean; Stephen J. Simpson; Samantha M. Solon...
• Keywords: Male; Pediatric Obesity; 0303 health sciences; Body Weight; Maternal Nutritional Physiological Phenomena; Nutrients; Mice; Eating; 03 medical and health sciences; Diet, Western; Prenatal Exposure Delayed Effects; Humans; Animals; Female

Abstract Objective Exposure in utero to maternal diet can program offspring health and susceptibility disease. Using C57BL6/JArc mice, we investigated how dietary protein carbohydrate balance influences male female appetite metabolic health. Methods Dams were placed on either a low‐protein (LP) or high‐protein (HP) diet. Male food choice experiment post weaning then constrained standard Western Food intake, body weight, composition measured, various tests performed at different timepoints. Results Offspring from mothers fed HP diets selected higher intake had increased weight early life relative LP diet‐fed dams. As predicted by leverage theory, targets led when no‐choice diets, resulting greater fat mass. The combination of an further exacerbated this obesity phenotype long‐term consequences for metabolism. Conclusions This work could help explain the association between elevated humans during risk childhood later life.