Synthesis,Antidiabetic and Antitubercular Evaluation of Quinoline–pyrazolopyrimidine hybrids and Quinoline‐4‐Arylamines

• DOI: 10.1002/open.202400014
• Publication Date: 2024-03-20T13:29:20Z
• Authors: Nosipho Cele; Paul Awolade; Pule Seboletswe; Lungisani Khubone; Kolawole Olofinsan; Md. Shahidul Islam; Audrey Jordaan; Digby F. Warner; Parvesh Singh
• Keywords: Quinoline; Moiety; IC50; Docking (animal); Aromatic amine

Two libraries of quinoline-based hybrids 1-(7-chloroquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and 7-chloro-N-phenylquinolin-4-amine were synthesized evaluated for their α-glucosidase inhibitory antioxidant properties. Compounds with 4-methylpiperidine para-trifluoromethoxy groups, respectively, showed the most promising inhibition activity IC