Site‐independent prognostic value of chromosome 9q loss in primary gastrointestinal stromal tumours

• DOI: 10.1002/path.1537
• Publication Date: 2004-04-06T22:01:16Z
• Authors: Bastian Gunawan; Hans‐Jürgen Schulten; Anja von Heydebreck; Bettina Schmidt; Christina Enders; Jörg Höer; Claus Langer; Phillip Schüler; Christian G Schin...; Jens Kuhlgatz; László Füzesi
• Keywords: Value (mathematics); Primary (astronomy)

Although the significance of tumour site for estimating malignant potential in gastrointestinal stromal tumours (GISTs) has recently been recognized, site-specific genetic patterns have not to date defined. This study examined 52 c-kit-positive primary GISTs (with a mean follow-up 42.3 months 51 cases) from three different locations (35 gastric, 12 small intestinal, and five colorectal) using comparative genomic hybridization (CGH). In general, correlated with key prognostic factors, including size, mitotic rate, proliferative activity, probable potential. Furthermore, several DNA copy number changes showed site-dependent pattern. These included losses at 14q (gastric 83%, intestinal 35%; p = 0.001), 22q 46%, 82%; 0.02), 1p 23%, 88%; 1 x 10(-5)), 15q 14%, 59%; 0.002), 9q 53%; 0.006), gains 5p 11%, 0.002). data demonstrate strong heterogeneity that may form basis subclassification. Prognostic evaluation identified as site-independent marker associated shorter disease-free survival (p 0.03) overall loss also appeared carry value predicting patients advanced or progressive 0.003).