Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

• DOI: 10.1002/path.2934
• Publication Date: 2011-05-10T11:46:47Z
• Authors: Jen‐Hui Tsou; Kung‐Chao Chang; Pey‐Yi Chang‐Liao; Shu‐Ting Yang; Chung‐Ta Lee; Ya‐Ping Chen; Yi‐Chao Lee; Bo‐Wen Lin; Jenq‐Chang Lee; Meng‐Ru Shen; Chin‐Kai Chuang; Wen‐Chang Chang; Ju‐Ming Wang; Liang‐Yi Hung
• Keywords: 0301 basic medicine; Epithelial Cells; Mice, SCID; Protein Serine-Threonine Kinases; 3. Good health; Up-Regulation; Gene Expression Regulation, Neoplastic; Mice; 03 medical and health sciences; Cell Transformation, Neoplastic; Aurora Kinases; Cell Movement; Mice, Inbred NOD; Animals; Aurora Kinase B; Humans; Aurora Kinase C; Female; Cell Proliferation

Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation clinical implications over-expressed cells are unclear. Here we show that elevated increases proliferation, transformation migration cells. Importantly, kinase activity is required for these tumour-associated properties. Analysis specimens shows expression increased cervical cancer, highly correlated with staging cancer. Over-expressed AURKC-GFP localizes to centromeric regions mitotic chromosomes results a decreased level AURKB, key regulator spindle checkpoint. Expression down-regulated by PLZF, transcriptional repressor, through recruitment its promoter region. The levels PLZF mRNA display opposite patterns cancers. Taken together, our provide important insights into cancers expression, which may serve as potential target therapy future.