Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization

• DOI: 10.1002/path.4628
• Publication Date: 2015-09-02T15:31:46Z
• Authors: Michael C Haffner; Christopher Weier; Meng Meng Xu; Ajay Vaghasia; Bora Gürel; Berrak Gümüşkaya; David M Esopi; Helen Fedor; Hsueh‐Li Tan; Ibrahim Kulac; Jessica Hicks; William B Isaacs; Tamara L Lotan; William G Nelson; Srinivasan Yegnas...; Angelo M De Marzo
• Keywords: Erg; Carcinoma in situ

Abstract Prostate cancer often manifests as morphologically distinct tumour foci and is frequently found adjacent to presumed precursor lesions such high‐grade prostatic intraepithelial neoplasia ( HGPIN ). While there some evidence suggest that these can be related exist on a pathological morphological continuum, the precise clonal temporal relationships between invasive cancers within individual tumours remain undefined. Here, we used molecular genetic, cytogenetic, histological analyses delineate clonal, temporal, spatial with features. First, while confirming previous finding substantial fraction of associated ERG‐positive share rearrangements overexpression ERG, significant subset glands exhibit only partial positivity for ERG. This suggests cells either rapidly invade form adenocarcinoma or represent have partially invaded ductal acinar space in retrograde manner. To clarify possibilities, ERG expression status TMPRSS2–ERG genomic breakpoints markers clonality, PTEN deletion track evolution clonally lesions. We confirmed nearby are related. Further, ‐positive, ‐negative intraductal carcinoma IDC ‐P) most likely derived from adenocarcinomas, indicating ‐P arise from, rather than give rise to, adenocarcinoma. These data mimic through colonization benign cells. Similar were also seen findings potentially undervalued indicator pre‐existing prostate implications diagnosis risk stratification. Copyright © 2015 Pathological Society Great Britain Ireland. Published by John Wiley & Sons, Ltd.