Increased dynamin expression precedes proteinuria in glomerular disease

• DOI: 10.1002/path.5181
• Publication Date: 2018-10-23T04:43:43Z
• Authors: Ramzi Khalil; Klaas Koop; Reinhold Kreutz; Herman P Spaink; Pancras CW Hogend...; Jan A Bruijn; Hans J Baelde
• Keywords: Nephrin

Abstract Dynamin plays an essential role in maintaining the structure and function of glomerular filtration barrier. Specifically, dynamin regulates actin cytoskeleton turnover nephrin podocytes, knocking down expression causes proteinuria. Moreover, promoting oligomerization with Bis‐T‐23 restores podocyte reduces proteinuria several animal models chronic kidney disease. Thus, is a promising therapeutic target for treating Here, we investigated pathophysiological under proteinuric circumstances rat model humans. We found that Dnm2 Dnm1 mRNA levels are increased prior to onset spontaneous Also, zebrafish embryos, confirm translation results Finally, show cathepsin L protein human diseases. propose reflects exhausted attempt maintain and/or restore integrity These important barrier, they support notion © 2018 The Authors. Journal Pathology published by John Wiley & Sons Ltd on behalf Pathological Society Great Britain Ireland.