N -Acetylcysteine Treatment of Rotavirus-Associated Diarrhea in Children

• DOI: 10.1002/phar.1489
• Publication Date: 2014-09-24T11:26:05Z
• Authors: Carlos A. Guerrero; Diana P. Torres; Leidy L. García; Rafael A. Guerrero; Orlando Acosta
• Keywords: Diarrhea; Male; 0301 basic medicine; Dehydration; Administration, Oral; Infant; Colombia; Antiviral Agents; Severity of Illness Index; Rotavirus Infections; Acetylcysteine; Gastroenteritis; 3. Good health; 03 medical and health sciences; Treatment Outcome; Recurrence; Child, Preschool; Diarrhea, Infantile; Humans; Female

Rotaviruses are the leading cause of severe, acute, and dehydrating diarrhea affecting children under 5 years age worldwide. Despite an important reduction in rotavirus-caused deaths as a consequence rotavirus vaccine, alternative or complementary strategies for preventing treating rotavirus-associated needed mainly poorest countries. We describe cases four rotavirus-unvaccinated 12–13-month-old girls 5-year-old boy who developed confirmed by enzyme-linked immunosorbent assay, Western blotting, immunochemistry analyses. After first day diarrheal episodes, three five patients were immediately administered oral N-acetylcysteine (NAC) 60 mg/kg daily, divided into equal doses every 8 hours. The other two did not receive NAC served controls. Administration resulted decreased number excretion fecal antigen, resolution symptoms after 2 days treatment. Our results suggest that treatment episode could be efficient strategy rotavirus-affected associated severe life-threatening accompanying dehydration.