Prevention of sporogony of Plasmodium vivax in Anopheles albimanus by steroids of Solanum nudum Dunal (Solanaceae)

• DOI: 10.1002/ptr.1874
• Publication Date: 2006-04-18T14:00:14Z
• Authors: Eliana Arango; Berlin Londoño; Cesar Segura; Yezid Solarte; Socrates Herrera; Jairo Saez; Jaime Carmona‐Fon...; Silvia Blair
• Keywords: Anopheles albimanus

The sporontocidal activity of three steroids (SN-1, SN-2 and SN-4) from Solanum nudum Dunal (Solanaceae) was determined against naturally circulating isolates Plasmodium vivax in Anopheles albimanus. Laboratory-reared albimanus mosquitoes were infected with P. gametocytemic blood volunteers resident Buenaventura, Valle del Cauca (Colombian Pacific Coast) by using an artificial membrane feeder. Prior to mosquito feeding, centrifuged, plasma separated, packed red cells washed RPMI 1640 then resuspended non-immune AB serum, the added at different doses. On day 7 after infection, presence number oocysts determined. steroid reduced infection 90% mean 60%. These data confirmed that experimental is capable interrupting sporogonic development This has potential for transmission blocking malaria.