Radioprotective effects of fucoidan in mice treated with total body irradiation

• DOI: 10.1002/ptr.2562
• Publication Date: 2008-08-06T16:57:19Z
• Authors: Jeeyoung Lee; Jeongtae Kim; Changjong Moon; Sung‐Ho Kim; Jin Won Hyun; Jae Woo Park; Taekyun Shin
• Keywords: Fucoidan; Total body irradiation; Ratón

Abstract The effects of fucoidan on the survival rate mice treated with total body irradiation were examined. BALB/c pretreated various doses prior to total‐body and monitored for 30 days. A significant improvement was observed by pretreatment at 100 mg/kg weight. Using this optimal dosage, examined radiation dose reduction analysis a factor (DRF) 1.20 determined days post‐irradiation. Mice also exhibited dose‐dependent increases in number bone marrow cells endogenous spleen cell colonies day 9 It is concluded that increased whole‐body irradiated may be attributable radioprotective hematopoietic viability, proliferation and/or mobility, possibly through antioxidation or antiinflammatory mechanisms. Copyright © 2008 John Wiley & Sons, Ltd.