Comparative haemodynamic effects of the flavonoids rhoifolin and vitexin in the dog

• DOI: 10.1002/ptr.2650040310
• Publication Date: 2006-10-18T04:17:39Z
• Authors: F. Occhiuto; C. Circosta; A. de Pasquale; F. Briguglio
• Keywords: 0301 basic medicine; 03 medical and health sciences; flavonoids,rhoifolin,vitexin,haemodynamic effects,cardiac catheterization in dogs

AbstractIn this communication we have examined the acute haemodynamic effects of two flavonoids with different electrophysiological characteristics, rhoifolin and vitexin, in anaesthetized dogs. The following haemodynamic parameters: mean aortic pressure, left ventricular systolic pressure, left ventricular end‐diastolic pressure, and its first derivative, mean arterial and pulmonary capillary wedge pressure, right atrial pressure and heart rate were measured. The results obtained have shown that rhoifolin and vitexin caused a decrease of mean aortic pressure, of the arterial and pulmonary capillary pressure and of heart rate. Differences in the left ventricular performance index of the two flavonoids were also noted.