Bile Acid‐binding Ability of Kaki‐tannin from Young Fruits of Persimmon (Diospyros kaki) In Vitro and In Vivo

• DOI: 10.1002/ptr.3306
• Publication Date: 2010-10-05T04:03:26Z
• Authors: Kenji Matsumoto; Akio Kadowaki; Natsumi Ozaki; Makiko Takenaka; Hiroshi Ono; Shin‐ichiro Yokoyama; Nobuki Gato
• Keywords: Bile Acids and Salts; Male; Mice, Inbred C57BL; 0301 basic medicine; Mice; 03 medical and health sciences; Spectroscopy, Fourier Transform Infrared; Animals; Diospyros; In Vitro Techniques; Tannins; Mass Spectrometry

AbstractThe bile acid‐binding ability of a highly polymerized tannin (kaki‐tannin) extracted from dried‐young fruits of persimmon (Diospyros kaki) was examined. The kaki‐tannin was composed mainly of epicatechin, epigallocatechin, epicatechin‐3‐O‐gallate and epigallocatechin‐3‐O‐gallate. Bile acid‐binding ability of kaki‐tannin was examined against cholic acid, glycocholic acid, taurocholic acid and deoxycholic acid in vitro, and its effect on fecal bile acid excretion in mice was also examined. Although the bile acid‐binding ability of kaki‐tannin was weaker than that of cholestyramine, kaki‐tannin adsorbed all the bile acids tested and significantly promoted fecal bile acid excretion in mice when supplied at 1% (w/w) in the diet. Copyright © 2010 John Wiley & Sons, Ltd.