Concentration Dependent Effect of (−)‐Epicatechin on Na+/K+‐ATPase and Ca2+‐ATPase Inhibition Induced by Free Radicals in Hypertensive Patients: Comparison with L‐ascorbic Acid

• DOI: 10.1002/ptr.4624
• Publication Date: 2012-02-27T10:25:13Z
• Authors: Navneet Kumar; Ruchi Kant; Pawan Kumar Maurya; Syed Ibrahim Rizvi
• Keywords: 0301 basic medicine; Ascorbic Acid; Calcium-Transporting ATPases; Middle Aged; Catechin; 3. Good health; Oxidative Stress; 03 medical and health sciences; tert-Butylhydroperoxide; Case-Control Studies; Hypertension; Humans; Enzyme Inhibitors; Sodium-Potassium-Exchanging ATPase

Although the antioxidant properties of flavonoids are well documented, it is still unclear whether these effects dependent on radical scavenging or iron chelating activities. Oxidative stress, a state excessive reactive oxygen species (ROS) activity, associated with vascular disease conditions such as hypertension. Both anti- and pro-oxidant tea catechins have been implicated in alterations cellular functions that determine their chemoprotective therapeutic potentials health diseases. The present study examined concentration (10(-7) to 10(-4) m) (-)-epicatechin L-ascorbic acid Na(+) /K(+) -ATPase Ca(2+) activity hypertensive patients normal subjects. has used positive control compare effect (-)-epicatechin. A significant (p < 0.0001) decrease activities was observed compared We report shows 0.001) dose-dependent protective against oxidative stress induced by tert-butyl hydroperoxide (t-BHP), which manisfested erythrocyte -ATPase, also comparable