The Effect ofZataria multifloraand its Constituent, Carvacrol, on Tracheal Responsiveness and Lung Pathology in Guinea Pig Model of COPD

• DOI: 10.1002/ptr.5309
• Publication Date: 2015-02-13T12:45:09Z
• Authors: L. Gholami Mahtaj; M.H. Boskabady; N. Mohamadian Roshan
• Keywords: Carvacrol

The effects of Zataria multiflora (Z. multiflora) and its constituent, carvacrol, in guinea pigs model chronic obstructive pulmonary disease (COPD) were examined. Animals divided into control, COPD, COPD + drinking water containing three concentrations extract Z. (0.4, 0.8 1.6 mg/ml), carvacrol (60, 120 240 µg/ml) dexamethasone (50 µg/ml). was induced by exposing animals to cigarette smoke for 3 months. Emphysema as a pathological change the lung tracheal responsiveness measured (n = 5 control groups n 6 another groups). Tracheal (p < 0.05) emphysema significantly increased 0.001) compared group. treated with two higher highest concentration improved Studied parameters also group 0.05 p 0.01). results indicated preventive effect on changes lung.