Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats

• DOI: 10.1002/ptr.5337
• Publication Date: 2015-04-07T11:18:58Z
• Authors: Hao Liu; Zhi Song; Da‐Guang Liao; Tian‐Yi Zhang; Feng Liu; Kai Zhuang; Kui Luo; Liang Yang; Jing He; Jian‐Ping Lei
• Keywords: Male; 0301 basic medicine; Electroshock; Mice, Inbred ICR; Epilepsy; Caspase 3; Glutamate Decarboxylase; Plant Extracts; Acorus; Brain; Glutamic Acid; Motor Activity; Lignans; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Proto-Oncogene Proteins c-bcl-2; Animals; Hypnotics and Sedatives; Anticonvulsants; Furans; Pentobarbital

This paper was designed to investigate anticonvulsant and sedative effects of eudesmin isolated from Acorus tatarinowii . The (5, 10, 20 mg/kg) administered intraperitoneally (i.p.). maximal electroshock test (MES) pentylenetertrazole (PTZ)‐induced seizures in male mice were used evaluate activities eudesmin, evaluated by pentobarbital sodium‐induced sleeping time (PST) locomotor activity mice. Finally, the mechanisms investigated determining contents glutamic acid (Glu) gamma‐aminobutyric (GABA) epileptic mice, expressions glutamate decarboxylase 65 (GAD65), GABA A , Bcl‐2, caspase‐3 brain chronic rats. Results MES PTZ tests revealed that possesses significant effects, PST demonstrated has effects. Furthermore, our study after treatment with increased, whereas Glu decreased, ratio Glu/GABA decreased. Our results also indicated GAD65, GABAA, Bcl‐2 up‐regulated treating obviously down‐regulated. In conclusion, mechanism may be related up‐regulation GAD65 expressions, anti‐apoptosis neuron brain. Copyright © 2015 John Wiley & Sons, Ltd.