The Beneficial Effect of Anthocyanidin‐Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High‐Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions

• DOI: 10.1002/ptr.5898
• Publication Date: 2017-08-25T06:41:39Z
• Authors: Gisele França da ...; Izabelle Barcello...; Graziele Freitas ...; Viviane Silva Cri...; Cristiane Aguiar ...; Lenize Costa Reis...; Dayane Teixeira O...; Angela Castro Res...; Roberto Soares de...
• Keywords: Resistin; GLUT4; Grape seed extract

We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by high-fat diet (HFD). C57/BL6 mice were fed standard (10% fat, control, GSE groups) or an HFD (60% high fat (HF), HF + GSE) with without (200 mg/kg/day) for 12 weeks. prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, resistin; deregulation leptin adiponectin expression adipose tissue. These be to positive modulation signaling proteins (IR, pIRS, PI3K, pAKT), pAMPK/AMPK ratio, GLUT4 muscle In addition, oxidative damage, evidenced restoration antioxidant activity decrease malondialdehyde carbonyl Finally, showed anti-inflammatory action, reduced tissue inflammatory markers (TNF-α, IL-6). Our results suggest HF-fed regulating sensitivity as well preventing stress inflammation skeletal Copyright © 2017 John Wiley & Sons, Ltd.