Anti‐MRSA activity of oxysporone and xylitol from the endophytic fungus Pestalotia sp. growing on the Sundarbans mangrove plant Heritiera fomes

• DOI: 10.1002/ptr.5983
• Publication Date: 2017-11-29T17:44:38Z
• Authors: Tauhidur Rahman N...; Lutfun Nahar; Shaymaa Al‐Majmaie; S.M. Mahbubur Rahman; Md. Hossain Sohrab; Md. Morsaline Billah; Fyaz M.D. Ismail; M. Mukhlesur Rahman; George P. Sharples; Satyajit D. Sarker
• Keywords: Fomes; Kandelia candel; Endophyte

Heritiera fomes Buch.-Ham., a mangrove plant from the Sundarbans, has adapted to unique habitat, muddy saline water, anaerobic soil, brackish tidal activities, and high microbial competition. Endophytic fungal association protects this adverse environmental conditions. This is used in Bangladeshi folk medicine, but it not been extensively studied phytochemically, there hardly any report on investigation endophytic fungi growing plant. In study, were isolated surface sterilized cladodes leaves of H. fomes. The antimicrobial activities evaluated against two Gram-positive Gram-negative bacteria strain, Candida albicans. Extracts Pestalotia sp. showed all test bacterial strains, except that ethyl acetate extract was inactive Escherichia coli. structures purified compounds, oxysporone xylitol, elucidated by spectroscopic means. anti-MRSA potential compounds determined various MRSA is, ATCC 25923, SA-1199B, RN4220, XU212, EMRSA-15, EMRSA-16, with minimum inhibitory concentration values ranging 32 128 μg/ml. paper, for first time, reports property isolation endophyte fomes, xylitol