Cytotoxicity of Tanshinone IIA combined with Taxol on drug‐resist breast cancer cells MCF‐7 through inhibition of Tau

• DOI: 10.1002/ptr.6014
• Publication Date: 2018-01-25T04:52:50Z
• Authors: Hui Lin; Luya Zheng; Shixiao Li; Bojian Xie; Binbin Cui; Aixiao Xia; Zhong Lin; Peng Zhou
• Keywords: MCF-7

Drug resistance represents a major obstacle to improving the overall response and survival of cancer patients. Taxol is one most commonly used chemotherapy agents in breast cancer. As with many therapeutic agents, remains significant problem when using treat malignancies. In this study, estrogen receptor positive cells MCF‐7 were induced resistance. And Tanshinone IIA combined was chosen it. The drugs combination showed additive effect drug concentrations. higher microtubule associated protein (Tau) expression, which considered as reasons for inhibited expression Tau resulted sensibility Taxol. Moreover, also cytotoxicity MCF‐7, might be related its estrogenicity effect. conclusion, resistant cells, inhibition Tau.