Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis

• DOI: 10.1002/ptr.7472
• Publication Date: 2022-05-02T12:30:00Z
• Authors: Di Zhang; Shiquan Chang; Xin Li; Huimei Shi; Bei Jing; Zhenni Chen; Yi Lin; Yachun Zheng; Guoqiang Qian; Yuwei Pan; Guoping Zhao
• Keywords: Paeoniflorin; Nerve Injury

Abstract Therapeutic drugs of chronic neuralgia have a high risk addiction, making it crucial to identify novel for neuralgia. This study aimed explore the therapeutic effect paeoniflorin on sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including sham operation group, constriction injury (CCI) mecobalamin and group. The mechanism evaluated rat experiments. Mechanical, hot, or cold hyperalgesia was induced in after CCI operation, while relieved Besides, decreased levels IL1, IL6, TNF‐α, CRP, LPS increased level IL10 serum. As sciatic nerve, number inflammatory cells decreased, present treatment, promoted recovery nerve structure. In experiments, apoptosis TLR4/NF‐kB pathway. And attenuated LPS‐induced by decreasing TLR4, p‐NF‐kB, caspase3, cleaved‐caspase3, cleaved‐caspase7. Overall, these results suggest that alleviates factor promotes repair damaged nerves reducing